Endocrine Abstracts

Our group studies the cell biological mechanisms of neurogenesis in the context of mammalian brain evolution, specifically the proliferation versus differentiation of neuroepithelial (NE) cells and their progeny. In the course of neurogenesis, mouse NE cells down-regulate a number of epithelial features. Expression of the anti-proliferative gene Tis21 can be used as a tool to distinguish between proliferating and neuron-generating NE cells. Time-lapse microscopy of neuron-gene...